Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis
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چکیده
منابع مشابه
Synthetic LXR ligand inhibits the development of atherosclerosis in mice.
The nuclear receptors LXRalpha and LXRbeta have been implicated in the control of cholesterol and fatty acid metabolism in multiple cell types. Activation of these receptors stimulates cholesterol efflux in macrophages, promotes bile acid synthesis in liver, and inhibits intestinal cholesterol absorption, actions that would collectively be expected to reduce atherosclerotic risk. However, synth...
متن کاملThe LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse.
Liver X receptor (LXR) ligands are currently being evaluated as potential therapeutic agents for the treatment of low HDL. The LXR ligand T0901317 elevates ATP binding cassette transporter A1 (ABCA1) and HDL levels in animal models and induces moderate lipogenesis through upregulation of sterol regulatory element binding protein 1c (SREBP1c). Because insulin may also regulate lipogenesis throug...
متن کاملSeparate and overlapping metabolic functions of LXR and LXR in C57Bl/6 female mice
Marion Korach-André, Paolo Parini, Lilian Larsson, Anders Arner, Knut R. Steffensen, and Jan-Åke Gustafsson Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet; Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital; Department of Physiology and Pharmacology, Karolinska Institutet, Huddinge, Sweden; and Cent...
متن کاملLXR antagonists induce ABCD2 expression.
X-linked adrenoleukodystrophy (X-ALD) is a rare neurodegenerative disorder characterized by the accumulation of very-long-chain fatty acids resulting from a beta-oxidation defect. Oxidative stress and inflammation are also key components of the pathogenesis. X-ALD is caused by mutations in the ABCDI gene, which encodes for a peroxisomal half ABC transporter predicted to participate in the entry...
متن کاملLiver X Receptor (LXR)- Regulation in LXR -Deficient Mice: Implications for Therapeutic Targeting
The nuclear receptors liver X receptor (LXR) LXR and LXR are differentially expressed ligand-activated transcription factors that induce genes controlling cholesterol homeostasis and lipogenesis. Synthetic ligands for both receptor subtypes activate ATP binding cassette transporter A1 (ABCA1)-mediated cholesterol metabolism, increase reverse cholesterol transport, and provide atheroprotection i...
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ژورنال
عنوان ژورنال: Theranostics
سال: 2021
ISSN: 1838-7640
DOI: 10.7150/thno.53139